Impact of an exercise program on muscular and functional performance and plasma levels of IL-6 and sTNFr1 in pre-frail community-dwelling older women: A randomized clinical trial

Publication year: 2012
Source:Archives of Physical Medicine and Rehabilitation

Lygia Paccini Lustosa, Leani Souza Máximo Pereira, Fernanda Matos Coelho, Daniele Sirineu Pereira, Juscélio Pereira Silva, Adriana Netto Parentoni, Rosângela Correa Dias, João Marcos Domingues Dias

Objective s: To examine the impact of the muscle resistance program (MRP) on muscular and functional performance and on IL-6 and soluble TNF receptor-1 (sTNFr1) plasma levels in pre-frail community-dwelling women. Design Randomized clinical trial-Cross over design with a post intervention and short term follow-up. Setting university hospital. Participants Thirty-two pre-frail community-dwelling women (≥65 years) Intervention The muscle resistance program was designed based on the exercise at 75% of each participant’s maximum load (10 week, 3 times/week). Main Outcome Measures Plasma concentrations of IL-6 and sTNFr1 (high sensitivity ELISA kits); muscle strength of the knee extensors (Isokinetic); functional performance (Timed up and go [TUG]; 10-m walk test [10MWT]). Results There were significant differences in functional and muscular performance between the pre--muscle resistance program (pre-MRP), post-muscle resistance program (post-MRP), and a 10-week follow-up period. After the muscle resistance program, both functional (TUG, pre-MRP = 11.1 seconds vs. post-MRP = 10.4 seconds, P = 0.00; 10MWT, pre-MRP = 4.9 seconds vs. post-MRP = 4.4 seconds, P = 0.00) and muscular performances (pre-MRP = 77.8% and post-MRP = 83.1%, P = 0.02) improved. After cessation of muscle resistance program (follow-up period), the sTNFr1 plasma levels increased by 21.4% at the 10-week follow up (post-MRP, 406.4 pg/ml; 10 week follow up, 517.0 pg/ml; p = 0.03). There was significant differences in sTNFr1 (P = 0.01). Conclusion The muscle resistance program was effective in improving functional and muscular performances, although alterations in plasma levels of IL-6 and sTNFr1 could not be identified after muscle resistance program. Cessation of the muscle resistance program during 10-week resulted in increased plasma levels of the sTNFr1.

Source: http://www.sciencedirect.com/science?_ob=GatewayURL&_origin=IRSSSEARCH&_method=citationSearch&_piikey=S000399931201115X&_version=1&md5=09263869fdcf594e71f7c3c96bb364c5

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